The germ layer mesoderm forms in the embryos of animals more complex than cnidarians, making them triploblastic. Mesoderm forms during gastrulation when some of the cells migrating inward to form the endoderm form an additional layer between the endoderm and the ectoderm. This key innovation evolved hundreds of millions of years ago and led to the evolution of nearly all large, complex animals. The formation of a mesoderm led to the formation of a coelom. Organs formed inside a coelom (body ca… (More on Mesoderm)