Depurination is a DNA alteration in which the hydrolysis of a purine base (Adenine or Guanine) from the deoxyribose-phosphate backbone occurs. After a depurination, the sugar phosphate backbone remains and the sugar ring has a hydroxyl (-OH) group in the place of the Adenine or Guanine. Around 1,000 Purines are lost this way each day in a typical mammalian cell. One of the main causes of depurination is the presence of endogenous metabolites in cell undergoing chemical reactions. This breaks the… (More on Depurination)