Altretamine (also hexalen) is a drug that's used to treat refractory ovarian cancer. It isn't considered a first-line treatment, but it can be useful as salvage therapy. It also has the advantage of being less toxic than other drugs used for treating refractory ovarian cancer. The precise mechanism by which altretamine exerts its anti-cancer effect is unknown, but it's classified by MeSH as an alkylating antineoplastic agent. Hydroxymethylmelamines are the active metabolite. It was approved by… (More on Altretamine)