s. Some chemists restrict the term to compounds with the charges on non-adjacent atoms. This would exclude compounds such as N-oxides and ylides, which have a charge on adjacent atoms, specificately, nitrogen and carbon being the cations, respectively. Zwitterions are polar and are usually very water-soluble, but poorly soluble in most organic solvents. Ampholytes are molecules that contain both acidic and basic groups (and are therefore amphoteric) and will exist mostly as zwitterions in a cert… (More on Zwitterion)