Phenacetin is an analgesic, but its use has declined owing to its association with several adverse side effects, some of which are described in the following. Typical doses are 300mg to 500mg a day. History Phenacetin was introduced in 1887, and was used principally as an analgesic, and was one of the first synthetic fever reducers to go on the market. It is also known historically to be one of the first non-opioid analgesics without anti-inflammatory properties. Known mechanism of action Its a… (More on Phenacetin)