In biochemistry, a ligase (from the Latin verb ligāre — "to bind" or "to glue together") is an enzyme that can catalyse the joining of two large molecules by forming a new chemical bond, usually with accompanying hydrolysis of a small chemical group pendant to one of the larger molecules. In general, ligase catalyses the following reaction: » Ab + C → A–C + b or sometimes » Ab + cD → A–D + b + c where the lowercase letters signify the small, pendant groups. No… (More on Ligases)