RLI's an essential and highly conserved protein that's required for both eukaryotic translation initiation as well as ribosome biogenesis. The most studied homologues are Rli1p in yeast and Pixie in Drosophila. Structure RLI's a 68 kDa cytoplasmic protein found in most eukaryota and archae. Since the crystal structure for RLI hasn't yet been determined, all that's known has been inferred from protein sequencing. The protein sequences between species's very well conserved, for example Pixie and… (More on Rli)