R22 or R-22 may refer to:* R22 (band), a metalcore/hard rock band from Brooklyn, New York R22 (New York City Subway car) R22 road (Senegal) , a risk phrase in chemistry Robinson R22, a small, light two-person helicopter USS R-22 (SS-99), a 1918 R-class coastal and harbor defense submarine of the United States Navy R-22, the refrigerant chlorodifluoromethane, a hydrochlorofluorocarbon used in air conditioning… (More on R-22)