Pepperoni's a spicy Italian-American variety of salami made from cured and fermented pork. In the USA, pepperoni can also be a mix of beef, chicken and pork. It's a descendant of the spicy salamis of Southern Italy, such as salsiccia Napoletana piccante, a spicy dry sausage from Naples or the Soppressata from Calabria. Pepperoni's a popular pizza topping in American-style pizzerias. Also, it's sometimes used to make sub sandwiches. Carrying the title of the literal Italian translation of "pepp… (More on Pepperoni)