Nociception (synonym: nocioception or nociperception)'s defined as "the neural processes of encoding and processing noxious stimuli." It's the afferent activity produced in the peripheral and central nervous system by stimuli that've the potential to damage tissue. Detection of noxious stimuli Mechanical, thermal, and chemical stimuli are detected by nerve endings called nociceptors, which are found in the skin and on internal surfaces such as the periosteum or joint surfaces. The concentration… (More on Nociception)