The House of Guise was a French ducal family, partly responsible for the French Wars of Religion. The Guises were Catholic, and Henry Guise wanted to end growing Calvinist influence. The assassination of Guise heightened passions and inspired Catholic attacks on Huguenots and their culture. The House of Guise was founded as a cadet branch of the House of Lorraine by Claude de Lorraine, first Duke of Guise (1496-1550), who entered French service and was made a duke by King François I. Claude… (More on Guises)