Gonadarche refers to the earliest gonadal changes of puberty. In response to pituitary gonadotropins, the ovaries in girls and the testes in boys begin to grow and increase the production of the sex steroids, especially estradiol and testosterone. In boys, testicular enlargement's the first physical sign of gonadarche, and usually of puberty. In girls, ovarian growth can't be directly seen, so thelarche and growth acceleration are usually the first evidence of gonadarche. Gonadarche should be… (More on Gonadarche)