Drusen (singular, "druse") are tiny yellow or white accumulations of extracellular material that build up in Bruch's membrane of the eye. The presence of a few small ("hard") drusen's normal with advancing age, and most people over 40 have some hard drusen. However, the presence of larger and more numerous drusen in the macula's a common early sign of age-related macular degeneration (AMD). Classification Drusen associated with aging and macular degeneration are distinct from another clinical e… (More on Drusen)