Depurination's a DNA alteration in which the hydrolysis of the beta-N-glycocidic link between a purine base (Adenine or Guanine) and the deoxyribose-phosphate backbone occurs. After a depurination, the sugar phosphate backbone remains and the sugar ring has a hydroxyl (-OH) group in the place of the Adenine or Guanine. Studies estimate that as many as 10,000 Purines are lost this way each day in a typical human cell, however this represents only 1/30,000 of the human genome. One of the main caus… (More on Depurination)