Carboxylation in chemistry's a chemical reaction in which a carboxylic acid group's introduced in a substrate. The opposite reaction's decarboxylation. Carboxylation in organic chemistry In organic chemistry many different protocols exist for carboxylation. One general approach's by reaction of nucleophiles with dry ice (solid carbon dioxide) or formic acid Carboxylation in biochemistry Carboxylation in biochemistry's a posttranslational modification of glutamate residues in proteins. It occurs… (More on Carboxylation)