5-MeO-DMT (5-methoxy-dimethyltryptamine)'s a powerful psychedelic tryptamine. It's found in a wide variety of plant and psychoactive toad species, and like its close relatives DMT and bufotenin (5-HO-DMT), it's been used as an entheogen by South American shamans for thousands of years. Chemistry 5-MeO-DMT was first synthesized in 1936, and in 1959 it was isolated as one of the psychoactive ingredients of Anadenanthera peregrina seeds used in preparing yopo snuff. It was once believed to be a ma… (More on 5-meo-dmt)