Year 1516 (MDXVI) was a leap year starting on Tuesday (link will display the full calendar) of the Julian calendar. Events of 1516 January – June March – With the death of Ferdinand II of Aragon, his grandson Charles of Ghent becomes King of Spain as Carlos I. April 23 – The Reinheitsgebot's instituted in Ingolstadt, Bavaria, regulating the purity of beer permissible for sale. July – December July – Selim I of the Ottoman Empire declares war on the Mamel… (More on 1516)